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Journal Article
Review
Pathology of GH-producing pituitary adenomas and GH cell hyperplasia of the pituitary.
Pituitary 2017 Februrary
INTRODUCTION: Histologic, immunohistochemical and electron microscopic studies have provided conclusive evidence that a marked diversity exists between tumors which secrete growth hormone (GH) in excess. GH cell hyperplasia can also be associated with acromegaly in patients with extrapituitary GH-releasing hormone secreting tumors or in familial pituitary tumor syndromes.
MATERIALS AND METHODS: A literature search was performed for information regarding pathology, GH-producing tumors and acromegaly.
RESULTS: This review summarizes the current knowledge on the morphology of GH-producing and silent GH adenomas, as well as GH hyperplasia of the pituitary.
CONCLUSION: The importance of morphologic classification and identification of different subgroups of patients with GH-producing adenomas and their impact on clinical management is discussed.
MATERIALS AND METHODS: A literature search was performed for information regarding pathology, GH-producing tumors and acromegaly.
RESULTS: This review summarizes the current knowledge on the morphology of GH-producing and silent GH adenomas, as well as GH hyperplasia of the pituitary.
CONCLUSION: The importance of morphologic classification and identification of different subgroups of patients with GH-producing adenomas and their impact on clinical management is discussed.
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