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JOURNAL ARTICLE
REVIEW
Direct Cardiac Cellular Reprogramming for Cardiac Regeneration.
Current Treatment Options in Cardiovascular Medicine 2016 September
OPINION STATEMENT: Direct cardiac cellular reprogramming of endogenous cardiac fibroblasts directly into induced cardiomyocytes is a highly feasible, promising therapeutic option for patients with advanced heart failure. The most successful cardiac reprogramming strategy will likely be a multimodal approach involving an optimal combination of cardio-differentiating factors, suppression of fibroblast gene expression, and induction of angiogenic factors.
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