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COMMENT
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
DNA (De)Methylation: The Passive Route to Naïvety?
Trends in Genetics : TIG 2016 October
Mouse pluripotent embryonic stem (ES) cells can exist in distinct yet interchangeable epigenetic states dictated by their culture environment. Previous reports have shown that naïve pluripotent cells grown in the presence of 2i are characterised by global DNA hypomethylation and changes in the abundance and distribution of histone modifications. New research provides insights regarding how this might be achieved.
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