Back Cover: Eur. J. Immunol. 8'16.

The cover shows a light sheet fluorescence microcopy image of a murine heart from diphtheria toxin treated CD11c-DTR mouse affected by fulminant myocarditis. The massive leukocyte infiltration was visualized by intravenous injection of fluorescent anti-CD45 antibodies. The autofluorescence channel reveals massive organ dilatation (grey). The leukocytic infiltrate is depicted in a heat map overlay from low (blue) to very high (bright yellow) and mainly affects the zone of the stimulus transduction system and the valves. The image is taken from Männ et al. (pp. 2028-2042) where the authors demonstrate, that a frequently used animal model for selective depletion of CD11c-expressing cells with diphtheria toxin suffers from a massive and 100% lethal phenotype of heart inflammation, which occurs within a few days after application of the toxin. This finding has important implications for previous and future studies using this animal model but may also provide a novel system to study fulminant myocarditis.