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IDH1, Histone Methylation, and So Forth.

Virginie Penard-Lacronique, Olivier A Bernard
Cancer Cell 2016 August 9
IDH mutants cause aberrant DNA and histone methylation and contribute to hematological and neuronal malignancies. In this issue of Cancer Cell, Inoue et al. describe a potential specific effect of IDH1 mutations that reduces Atm expression via inhibition of H3K9 demethylases, which may represent a first step toward cellular transformation.

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