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Journal Article
Review
[Role of Reelin during Layer Formation in the Cerebral Neocortex].
Brain and Nerve = Shinkei Kenkyū No Shinpo 2016 August
Reelin controls the neuronal layer formation in the developing cerebral neocortex. The Reelin glycoprotein is mainly secreted from Cajal-Retzius cells in the marginal zone, and it guides the proper aggregation of the migrating neurons in a birth-dependent "inside-out" manner. Reelin also regulates the final process of neuronal migration (terminal translocation and somal translocation) by activating integrin and N-cadherin. It is also expressed around the subventricular zone and it controls the behavior of the migrating neurons.
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