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Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
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Targeted Molecular Imaging of Cancer Cells Using MS2-Based (129)Xe NMR.

Keunhong Jeong, Chawita Netirojjanakul, Henrik K Munch, Jinny Sun, Joel A Finbloom, David E Wemmer, Alexander Pines, Matthew B Francis
Bioconjugate Chemistry 2016 August 18
We have synthesized targeted, selective, and highly sensitive (129)Xe NMR nanoscale biosensors using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyperpolarized (129)Xe NMR signal contrast and hyper-CEST (129)Xe MRI image contrast indicated its promise as highly sensitive hyperpolarized (129)Xe NMR nanoscale biosensor for future applications in cancer detection in vivo.

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