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Cytokeratin-19 fragment in the diagnosis of bladder carcinoma.
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine 2016 October
The results of previous studies evaluated the accuracy of serum, and urinary measurements of cytokeratin-19 fragment (CYFRA 21-1) for the diagnosis of bladder cancer were inconsistent. We read with great interest the recent systematic review of diagnostic accuracy of CYFRA 21-1 for bladder cancer by Huang et al. The systematic analysis demonstrated that the pooled sensitivities and specificities for serum and urine CYFRA 21-1 were 0.42 (95 % confidence interval (CI), 0.33-0.51), 0.82 (95 % CI, 0.70-0.90), 0.94 (95 % CI, 0.90-0.96), and 0.80 (95 % CI, 0.73-0.86), respectively. Areas under the summary receiver-operating-characteristic curves for serum and urine CYFRA 21-1 were 0.88 (95 % CI, 0.85-0.91) and 0.87 (95%CI, 0.84-0.90), respectively. The authors considered that both serum and urine CYFRA 21-1 served as efficient indexes for bladder-cancer diagnosis. We congratulate and applaud their important work, but several important issues should be noted.
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