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Targeting KIR Blockade in Multiple Myeloma: Trouble in Checkpoint Paradise?

Martin Felices, Jeffrey S Miller
Clinical Cancer Research 2016 November 2
Findings within the current issue indicate that treatment with IPH2101 when used as a monotherapy in smoldering multiple myeloma, meant to enhance natural killer (NK) cell function through inhibitory KIR blockade, results in a surprising reduction of NK-cell function mediated through monocyte trogocytosis. The significance of these findings is discussed. Clin Cancer Res; 22(21); 5161-3. ©2016 AACRSee related article by Carlsten et al., p. 5211.

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