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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Flow Chemistry on Multigram Scale: Continuous Synthesis of Boronic Acids within 1 s.
Organic Letters 2016 August 6
The benefits and limitations of a simple continuous flow setup for handling and performing of organolithium chemistry on the multigram scale is described. The developed metalation platform embodies a valuable complement to existing methodologies, as it combines the benefits of Flash Chemistry (chemical synthesis on a time scale of <1 s) with remarkable throughput (g/min) while mitigating the risk of blockages.
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