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Metabolic RemodeLIN of Pluripotency.

Julie Mathieu, Hannele Ruohola-Baker
Cell Stem Cell 2016 July 8
Cellular metabolism is a key regulator of cell fate, including fate in pluripotent stem cells. Now in Cell Stem Cell, Zhang et al. (2016) show that Lin28 controls the metabolic transition from naive to primed pluripotency by directly repressing oxidative metabolism genes and metabolic intermediates involved in epigenetic regulation independently of let-7.

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