Physiological Significance of Well-tolerated Inspiratory Pressure to Chronic Obstructive Pulmonary Disease Patient with Hypercapnia During Noninvasive Pressure Support Ventilation.

The inspiratory pressure is often set by tolerance of chronic obstructive pulmonary disease (COPD) patient during noninvasive pressure support ventilation (PSV). However, physiological effects of this setting remain unclear. This study was undertaken to assess the physiological effect of highest tolerated assist level on COPD patient.  The baseline inspiratory pressure (PS) was titrated by tolerance in 15 severe COPD patients with hypercapnia during acute exacerbation. In addition to the baseline PS, an additional decrease by 25% (PS- = 75% PS) or increase by 25% (PS+ = 125% PS) of PS was applied to the patients. Each level lasted at least 20 minutes. Respiratory rate (RR), tidal volume (Vt), inspiratory effort (PTPpes in/min), and neuro-ventilatory coupling (VE/RMS%) were measured. Asynchrony Index (AI) was calculated.  The Vt and VE/RMS% were significantly increased by PS level (Vt: 561 ± 102 ml, VE/RMS%: 1.06 ± 0.42 L/%, comfort score: 7.5 ± 1.1). The inspiratory muscles were sufficiently unloaded (PTPpes in/min 56.67 ± 32.71 cmH2 O.S/min). In comparison with PS, PS+ resulted in a further increase in Vt, VE/RMS% and AI (P < 0.01), with no further reduction in neural drive (RMS) and respiratory muscle activity (P > 0.05).  Increasing inspiratory pressure significantly enhances the VE/RMS% and Vt. However, the inspiratory pressure higher than COPD patient's most tolerated level cannot lead to further reduction in respiratory muscle load and RMS, but more asynchrony events. Physiological data can monitor the patient's responses and the ventilator-patient interaction, which may provide objective criterion to ventilator setting.