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Activation of human bitter taste receptors by polymethoxylated flavonoids.

Yuki Kuroda, Riko Ikeda, Toyomi Yamazaki, Keisuke Ito, Kazunari Uda, Keiji Wakabayashi, Tatsuo Watanabe
Bioscience, Biotechnology, and Biochemistry 2016 October
Tangeretin and nobiletin are polymethoxylated flavonoids in citrus peel. Both tangeretin and nobiletin are bitter; however, their bitterness has not been evaluated using human bitter taste receptors (hTAS2Rs). We screened 25 kinds of hTAS2Rs and found that hTAS2R14 and hTAS2R46 received both compounds.

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