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FLCN: A new regulator of AMPK-dependent Warburg metabolic reprogramming.
Molecular & Cellular Oncology 2014 April
Tumor cells manage their energy to support aberrant proliferation by reprogramming their cellular metabolism, for example through the Warburg effect. Although AMPK is a major regulator of energy homeostasis, its role in cancer metabolic adaptation is unclear. We recently identified the tumor suppressor folliculin as a new regulator of AMPK-dependent metabolic transformation.
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