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Paramagnetic lanthanide chelates for multicontrast MRI.

Nevenka Cakić, Tanja Savić, Janice Stricker-Shaver, Vincent Truffault, Carlos Platas-Iglesias, Christian Mirkes, Rolf Pohmann, Klaus Scheffler, Goran Angelovski
Chemical Communications : Chem Comm 2016 July 29
The preparation of a paramagnetic chelator that serves as a platform for multicontrast MRI, and can be utilized either as a T1-weighted, paraCEST or (19)F MRI contrast agent is reported. Its europium(iii) complex exhibits an extremely slow water exchange rate which is optimal for the use in CEST MRI. The potential of this platform was demonstrated through a series of MRI studies on tube phantoms and animals.

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