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Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
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Magnetic Multivalent Trehalose Glycopolymer Nanoparticles for the Detection of Mycobacteria.

Xuan Chen, Bin Wu, Kalana W Jayawardana, Nanjing Hao, H Surangi N Jayawardena, Robert Langer, Ana Jaklenec, Mingdi Yan
Advanced Healthcare Materials 2016 August
A multivalent trehalose-grafted poly(lactic acid) is synthesized and encapsulated with iron oxide magnetic nanoparticles. The magnetic micelles interact with Mycobacterium smegmatis to form orange clusters. Very little particle interaction is found on Staphylococcus epidermidis 35984 or Escherichia coli ORN 208. The presented new approach to the detection of mycobacteria does not require molecular biology reagents or sophisticated instruments.

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