Clopidogrel loading dose in the management of ST elevation myocardial infarction: Still a debate!

Clopidogrel as a potent antiplatelet agent is administered in patients with ST elevation myocardial infarction (STEMI). The efficacy and safety of 2 clopidogrel loading regimen (300 mg vs 600 mg) in STEMI patients undergoing a primary percutaneous coronary intervention is still under investigation. The purpose of this article is to highlight current knowledge and guidelines regarding clopidogrel loading dose and also time of administration in STEMI setting and before primary percutaneous coronary intervention.