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Journal Article
Review
A possible new role for Aβ in vascular and inflammatory dysfunction in Alzheimer's disease.
Thrombosis Research 2016 May
Alzheimer's disease (AD) is often characterized by vascular pathology, a procoagulant state, and chronic inflammation. The mechanisms behind these abnormalities in AD are not clear. Here, we review evidence for the role of the AD-associated peptide Aβ in promoting inflammation and thrombosis in AD via its interaction with the circulating proteins factor XII and fibrinogen.
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