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The preventive effect of Flavonoids on Aldose Reductase and Protein Glycation in diabetic complications.

Diabetic patients are susceptible to the development of chronic health complications responsible for a significant increase in their morbidity and mortality. Mechanisms related to glucose toxicity, namely oxidative stress, processes of non-enzymatic glycation and enhanced polyol pathway significantly contribute to the development of secondary complications of diabetes. There is an urgent need for inexpensive, non-surgical approaches to the treatment of diabetic complications. Recently, considerable attention has been devoted to the search for phytochemical therapeutics. Several pharmacological actions of natural flavonoids may operate in the prevention of cataract since flavonoids are capable of affecting multiple mechanisms or etiological factors responsible for the development of diabetic complications. In the present chapter, flavonoids are reviewed as potential agents that could reduce the risk of diabetes via affecting multiple pathways pertinent to secondary complications of diabetes.

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