We have located links that may give you full text access.
Evaluation of a tailored injection profile (TIP) algorithm for uniform contrast-enhanced signal intensity profiles in MR angiography.
Journal of Magnetic Resonance Imaging : JMRI 2016 December
PURPOSE: To evaluate a contrast agent injection method that provides constant magnetic resonance imaging (MRI) signal intensity throughout a contrast-enhanced MR angiography acquisition.
MATERIALS AND METHODS: A tailored injection profile (TIP) algorithm was developed that used the signal intensity profile from a test bolus as an impulse response function, and predicted the response to various multiphasic injection profiles. Antecubital vein injections were administered via a commercially available multiphasic power injector. The TIP algorithm evaluated the predicted responses and selected the injection that best matched the desired (20-sec plateau) profile. Resulting signal intensity profiles from tailored and standard injection profiles were compared in 20 subjects (10 each). All subjects received a weight-based single-dose (0.1 mmol/kg) of gadoteridol, and abdominal aorta signal intensities were measured at 3T with a time-resolved, thick-slice, 3D spoiled-gradient-echo MR sequence with parameters approximating contrast-enhanced MR angiography. The single-phase, standard injection was injected at 1.6 mL/sec.
RESULTS: Full-width at 80% maximum (FW80M) signal intensity was significantly longer for the tailored injection profiles (23.0 ± 2.2 vs. 9.0 ± 4.2 sec; P < 0.01). Concurrently, the profile peak signal intensity was reduced by 19% for the tailored profiles (12.0 ± 3.1 vs. 14.8 ± 2.8 times baseline; P = 0.058), nearly reaching significance.
CONCLUSION: Multiphasic tailored injections from a power injector produced longer signal intensity profiles (156% increase in FW80M) with an accompanying decrease (19%) in peak signal intensity compared to a standard, single-phase injection. J. Magn. Reson. Imaging 2016. J. Magn. Reson. Imaging 2016;44:1664-1672.
MATERIALS AND METHODS: A tailored injection profile (TIP) algorithm was developed that used the signal intensity profile from a test bolus as an impulse response function, and predicted the response to various multiphasic injection profiles. Antecubital vein injections were administered via a commercially available multiphasic power injector. The TIP algorithm evaluated the predicted responses and selected the injection that best matched the desired (20-sec plateau) profile. Resulting signal intensity profiles from tailored and standard injection profiles were compared in 20 subjects (10 each). All subjects received a weight-based single-dose (0.1 mmol/kg) of gadoteridol, and abdominal aorta signal intensities were measured at 3T with a time-resolved, thick-slice, 3D spoiled-gradient-echo MR sequence with parameters approximating contrast-enhanced MR angiography. The single-phase, standard injection was injected at 1.6 mL/sec.
RESULTS: Full-width at 80% maximum (FW80M) signal intensity was significantly longer for the tailored injection profiles (23.0 ± 2.2 vs. 9.0 ± 4.2 sec; P < 0.01). Concurrently, the profile peak signal intensity was reduced by 19% for the tailored profiles (12.0 ± 3.1 vs. 14.8 ± 2.8 times baseline; P = 0.058), nearly reaching significance.
CONCLUSION: Multiphasic tailored injections from a power injector produced longer signal intensity profiles (156% increase in FW80M) with an accompanying decrease (19%) in peak signal intensity compared to a standard, single-phase injection. J. Magn. Reson. Imaging 2016. J. Magn. Reson. Imaging 2016;44:1664-1672.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app