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Research Support, Non-U.S. Gov't
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[Inhibitory Properties of Nitrogen-Containing Adamantane Derivatives with Monoterpenoid Fragments Against Tyrosyl-DNA Phosphodiesterase I].

A L Zakharenko, K U Ponomarev, E V Suslov, D V Korchagina, K P Volcho, I A Vasil'eva, N F Salakhutdinov, O I Lavrik
Bioorganicheskaia Khimiia 2015 November
It was found that compounds combining diazaadamantane and monoterpenoid fragments are potent inhibitors of new structural type of human recombinant DNA repair enzyme Tyrosyl-DNA phosphodiesterase I (Tdp1). It was demonstrated that the inhibition efficiency depended on the length and flexibility of the aliphatic chain of the substituent.

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