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Increase in urinary markers during the acute phase reflects the degree of chronic tubulointerstitial injury after ischemia-reperfusion renal injury.

CONTEXT: Acute kidney injury (AKI) could lead to progressive chronic kidney disease (CKD).

OBJECTIVES: To demonstrate that urinary markers in AKI are associated with the degree of persistent renal injury.

MATERIAL AND METHODS: Human L-FABP chromosomal transgenic (Tg ) mice were subjected to ischemia-reperfusion (I/R) clamping renal pedicle for 20 min or 30 min. Kidneys were obtained at one and 40 days after I/R.

RESULTS: Urinary L-FABP, NGAL, Kim-1 and albumin levels increased during the acute phase and were significantly correlated with the degree of tubulointerstitial fibrosis during the chronic phase.

DISCUSSION AND CONCLUSION: These markers could detect higher risk of progression to CKD.

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