[The measures of autonomic homeostasis as predictors of an individual risk of stroke and their dynamics during therapy with actovegin].

OBJECTIVE: To evaluate an individual 10-year risk of stroke in patients with chronic cerebral ischemia, identify predictors of this risk and assess its dynamics during therapy with actovegin.

MATERIAL AND METHODS: The measures of autonomic homeostasis were estimated in 54 patients with chronic brainstem ischemia. The dynamics of these indexes during therapy with actovegin was studied.

RESULTS AND CONCLUSION: Chronic cerebral ischemia, mostly vertebrobasilar ischemia, is correlated with an increasing individual 10-year risk of stroke. A high positive pharmacologic effect of actovegin on the central and peripheral structures of the autonomic nervous system in chronic cerebral ischemia has been shown. A mediated hypotensive effect of actovegin due to humoral, metabolic and neurogenic influences on a vessel wall has been demonstrated.