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Journal Article
Combinatorial Antigen Targeting: Ideal T-Cell Sensing and Anti-Tumor Response.
Trends in Molecular Medicine 2016 April
T cells expressing chimeric antigen receptors (CARs) are a formidable platform for the study and application of synthetic biology approaches to study customized and flexible control of cellular functions. Recent reports in the journal Cell provide a new twist on combinatorial antigen targeting, profiting from the singular cleavage and signaling of the Notch receptor to conditionally express CARs.
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