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Journal Article
Research Support, Non-U.S. Gov't
Review
Identification of lysocin E using a silkworm model of bacterial infection.
Drug Discoveries & Therapeutics 2016 Februrary
New antimicrobials with novel mechanisms need to be developed to combat antimicrobial-resistant pathogenic bacteria. The current authors recently reported discovery of a new antibiotic named "Lysocin E". Lysocin E was identified using a silkworm model of bacterial infection. The current review discusses the advantages of using a silkworm model of bacterial infection to identify and develop therapeutically efficacious antimicrobials. This review also discusses the discovery of lysocin E and its novel mechanism of action.
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