Preeclampsia and future cardiovascular risk: A point of view from the clearance of plasma vasoactive amines.

Shi-Sheng Zhou, Yi-Ming Zhou, Da Li, Na-Na Chen

Hypertension in Pregnancy 2016

OBJECTIVE: To summarize the reported evidence on the relationship between vasoactive amines and preeclampsia.

METHODS: A literature search was conducted in MEDLINE/PubMed and EMBASE.

RESULTS: The summarized results are as follows: (1) Menstruation can effectively eliminate vasoactive amines norepinephrine, serotonin and histamine. (2) Pregnancy increases norepinephrine production due to fetal brain development and decreases vasoactive-amine elimination due to amenorrhea. (3) Preeclampsia is associated with a low renal and/or sweating capacity, or in rare cases, with increased norepinephrine production due to maternal pheochromocytoma and fetal neuroblastoma.

CONCLUSION: Preeclampsia is mainly due to decreased excretion of norepinephrine and other vasoactive amines.

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