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Journal Article
Research Support, N.I.H., Extramural
Review
The physiological and clinical importance of sodium potassium ATPase in cardiovascular diseases.
Current Opinion in Pharmacology 2016 April
The Na/K-ATPase has been extensively studied, but it is only recently that its role as a scaffolding and signaling protein has been identified. It has been identified that cardiotonic steroids (CTS) such as digitalis mediate signal transduction through the Na/K-ATPase in a process found to result in the generation of reactive oxygen species (ROS). As these ROS also appear capable of initiating this signal cascade, a feed forward amplification process has been postulated and subsequently implicated in some disease pathways including uremic cardiomyopathy.
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