We have located links that may give you full text access.
vwF A3-GPI modification of EPCs accelerates reendothelialization of injured vessels via collagen targeting in mice.
Journal of Drug Targeting 2016 September
Despite the potential of endothelial progenitor cells (EPCs) to incorporate into sites of vessel injury and differentiate into endothelial cells, thereby contributing to the improvement of endothelial function, reendothelialization in some patients is insufficient for the prevention of abnormal endothelial growth because there is a lack of specific guided signals and low levels of congregation of the EPCs to the injured areas. If some type of molecular tool was able to guide EPCs specifically to the injured vessels, however, then the efficacy of cell implantation would improve. Here, we designed a strategy to modify these cells and improve their ability to directly target the injured vessels. As a homing molecule, we selected extracellular matrix components, such as collagen, which is exposed on catheter-injured arteries. To promote the adhesion of the EPCs to collagen, we painted the primary EPCs with a recombinant, glycosylphosphatidylinositol (GPI)-linked high-affinity ligand for collagen that is termed von Willebrand factor A3-GPI. These painted EPCs specifically bound to collagen in vitro and traveled to the damaged vessel in vivo. This novel strategy may allow for significant advancements in EPCs transplantation treatment.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
Perioperative echocardiographic strain analysis: what anesthesiologists should know.Canadian Journal of Anaesthesia 2024 April 11
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app