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Effect of lanosterol on human cataract nucleus.

P Mahesh Shanmugam, Aditya Barigali, Jayant Kadaskar, Sandip Borgohain, Divaynsh Kailash Chandra Mishra, Rajesh Ramanjulu, C K Minija
Indian Journal of Ophthalmology 2015 December
AIM: To study the effect of lanosterol on age-related cataractous human lens nuclei.

MATERIALS AND METHODS: Forty age-related cataractous nuclei removed during manual small incision cataract surgery were obtained and randomly immersed in 25 mM lanosterol solution or in control solution and stored at room temperature for 6 days. Pre- and post-immersion photographs were graded by two masked observers and collated for the regression or progression of lens opacity.

RESULTS: Both lanosterol and control groups showed progression or no change in the lens opacity at the end of 6 days.

CONCLUSION: Lanosterol 25 mM solution did not reverse opacification of human age-related cataractous nuclei.

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