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[Early Stages of Parkinson's Disease: Comparative Characteristics of Sleep-Wakefulness Cycle in Patients and Model Animals].

V M Kovalzon, M V Ugrumov, T S Pronina, V B Dorokhov, A I Manolov, V V Dolgikh, Y V Ukraintseva, L S Moiseenko, M G Poluektov, A L Kalinkin
Fiziologiia Cheloveka 2015 November
The results of study of sleep-wakefulness cycle in experimental models of pre-clinical and early clinical stages of Parkinson's disease present and compared to some clinical examples. The conclusion is, the increase in activity level and decrease in total amount of slow wave and paradoxical sleep in model animals are taking place at the same circadian period of the secretion of pineal melatonin as sleep disorders in patients.

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