[Value explore and correlation analysis on pulmonary artery pressure and brain natriuretic peptide predicting prognosis in septic shock patients].

OBJECTIVE: To evaluate and explore the relationship among the pulmonary artery pressure, Brain natriuretic peptide and the prognosis in the patients with septic shock.

METHODS: From May 2013 to Oct. 2014, 48 patients were treated with Swan-Ganz catheter to monitor the pulmonary artery pressure, the pulmonary vascular resistance, the pulmonary capillary wedge pressure and cardiac output. Testing brain natriuretic peptide, Analysising the differences between survival patients (27 cases) and dead patients (21 cases) in the PAP, PVR, PCWP, CO and BNP, Analysising the correlation between BNP and PAP, PVR, PCWP, CO by Linear correlation analysis.

RESULTS: It is no difference in hemodynamic parameters between dead patients and survival patients when they come in the hospital (P > 0.05); it is significant difference in hemodynamic parameters between dead patients and survival patients when they came in the hospital after 48 hours or 72 hours [(20.8 ± 5.8) mmHg vs (34.2 ± 7.4) mmHg, P < 0.05], it is no difference in PVR, PCWR and CO at 24 hours, 48 hours or 72 hours. Then it is significant difference in BNP between dead patients and survival patients that they had been entered the hospital after 48 hours or 72 hours [(286.5 ± 75.5) pg/ml vs (675.4 ± 51.3) pg/ml, P < 0.05], it has no obvious correlation among the BNP, PAP and CO.

CONCLUSIONS: It prompts a poor prognosis if the patients with septic shock had increased the pulmonary artery pressure and the BNP. Therefore it is need focus on pulmonary hypertension, it is different if BNP of plasma in heart failure patients increased, it does not mean heart function failuring, so it can not be used to give a guide to therapy on heart function.