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Infective Endocarditis in Children in Italy from 2000 to 2015

Susanna Esposito, Alessandra Mayer, Andrzej Krzysztofiak, Silvia Garazzino, Rita Lipreri, Luisa Galli, Patrizia Osimani, Emilio Fossali, Maria Di Gangi, Laura Lancella, Marco Denina, Giulia Pattarino, Carlotta Montagnani, Filippo Salvini, Alberto Villani, Nicola Principi, Italian Pediatric Infective Endocarditis Registry
Expert Review of Anti-infective Therapy 2016, 14 (3): 353-8

OBJECTIVE: The Italian Society for Pediatric Infectious Diseases created a registry on children with infective endocarditis (IE) hospitalized in Italy.

METHODS: A cross-sectional survey was conducted on patients hospitalized due to IE in Italian paediatric wards between January 1, 2000, and June 30, 2015.

RESULTS: Over the 15-year study period, 47 IE episodes were observed (19 males; age range, 2-17 years). Viridans Streptococci were the most common pathogens among patients with predisposing cardiac conditions and Staphylococcus aureus among those without (37.9% vs. 5.5%, p = 0.018, and 6.9% vs. 27.8%, p = 0.089, respectively). Six of the 7 (85.7%) S. aureus strains were methicillin-resistant. The majority of patients with and without predisposing cardiac conditions recovered without any complications.

CONCLUSION: In Italy, paediatric IE develops without any previous predisposing factors in a number of children, methicillin-resistant S. aureus has emerged as a common causative agent and the therapeutic approach is extremely variable.


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