Successful use of Tenecteplase in a patient with recurrence of prosthetic mitral valve thrombosis.

INTRODUCTION: Tenecteplase can be a more effective and convenient alternative in treatment of prosthetic valve thrombosis (PVT).

CASE: We hereby present a case of the use of Tenecteplase for recurrence of mitral valve thrombosis in a patient who was brought as an emergency with breathing difficulty at rest. A single intravenous bolus of Tenecteplase relieved her symptoms dramatically within a few hours. This is in contradistinction to her earlier similar presentation with valve thrombosis a year back, when both streptokinase and urokinase had not worked.

CONCLUSION: The use of Tenecteplase in PVT is reasonable, but needs more documentation. The therapeutic response was remarkable in our case. It is also better suited for recurrence of valve thrombosis as streptokinase cannot be used for a second time.