Microtubule Organization in the Axon: TRIM46 Determines the Orientation.

Michele Curcio, Frank Bradke

Neuron 2015 December 17

The microtubule cytoskeleton is a major determinant in neuronal polarity. In this issue of Neuron, van Beuningen et al. (2015) now report that TRIM46 forms parallel microtubule bundles in the proximal axon and reveal that it is crucial for the establishment and maintenance of neuronal polarity.

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