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Journal Article
Randomized Controlled Trial
Zinc Supplementation in Preterm Neonates and Neurological Development, A Randomized Controlled Trial.
Indian Pediatrics 2015 November
OBJECTIVE: To assess the effect of zinc supplementation on neuro-development and growth of preterm neonates.
SETTING: Referral neonatal unit of a teaching hospital.
DESIGN: Open-labeled Randomized controlled trial.
PARTICIPANTS: 100 preterm neonates.
INTERVENTION: Participants randomized to receive oral zinc (study group) or not (controls).
MAIN OUTCOME MEASURES: Primary: Neuro-development status at 40 weeks post conceptional age and at 3 month corrected age using Amiel-Tison neurologic assessment. Secondary: anthropometry and serum alkaline phosphatase at 3 months corrected age.
RESULTS: At 40 weeks post-conceptional age, greater number of zinc supplemented infants demonstrated alertness and attention pattern normal for their age (P=0.02). Higher number of controls showed signs of hyper-excitability at 40 week post-conceptional age (P=0.001) and 3 months corrected age (P=0.003). At 3 month corrected age, mean serum alkaline phosphatase level was significantly higher in the study group compared to controls.
CONCLUSION: Zinc supplementation till 3 month corrected age in preterm breastfed infants improves alertness and attention pattern; and decreases signs of hyperexcitability, and proportion with abnormal reflexes.
SETTING: Referral neonatal unit of a teaching hospital.
DESIGN: Open-labeled Randomized controlled trial.
PARTICIPANTS: 100 preterm neonates.
INTERVENTION: Participants randomized to receive oral zinc (study group) or not (controls).
MAIN OUTCOME MEASURES: Primary: Neuro-development status at 40 weeks post conceptional age and at 3 month corrected age using Amiel-Tison neurologic assessment. Secondary: anthropometry and serum alkaline phosphatase at 3 months corrected age.
RESULTS: At 40 weeks post-conceptional age, greater number of zinc supplemented infants demonstrated alertness and attention pattern normal for their age (P=0.02). Higher number of controls showed signs of hyper-excitability at 40 week post-conceptional age (P=0.001) and 3 months corrected age (P=0.003). At 3 month corrected age, mean serum alkaline phosphatase level was significantly higher in the study group compared to controls.
CONCLUSION: Zinc supplementation till 3 month corrected age in preterm breastfed infants improves alertness and attention pattern; and decreases signs of hyperexcitability, and proportion with abnormal reflexes.
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