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JOURNAL ARTICLE
RESEARCH SUPPORT, N.I.H., EXTRAMURAL
The spliceosome, a potential Achilles heel of MYC-driven tumors.
Genome Medicine 2015 October 23
Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome - the core splicing machinery - that are essential for malignant transformation driven by the transcription factor MYC. These findings provide a direct link between MYC and RNA splicing deregulation, and raise the exciting possibility of targeting spliceosome components in MYC-driven tumors.
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