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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
In vivo fluorescence imaging of β-amyloid plaques with push-pull dimethylaminothiophene derivatives.
Chemical Communications : Chem Comm 2015 December 15
In vivo fluorescence imaging of β-amyloid (Aβ) plaques in the brain is expected to be used as a new method for detecting Alzheimer's disease (AD). We synthesized novel push-pull dimethylaminothiophenyl (DTM) derivatives and evaluated their utility as in vivo fluorescence imaging probes targeting Aβ plaques. As a result, we found that DTM-2 is a promising fluorescent probe for Aβ plaques in the AD brains.
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