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Exosomes and CAFs: partners in crime.

Benedetta Apollonio, Alan G Ramsay
Blood 2015 August 28
In this issue of Blood, Paggetti et al present novel findings that chronic lymphocytic leukemia (CLL)-derived exosomes and their molecular cargo are actively transferred to stromal cells that reside in the lymphoid tumor microenvironment (TME), promoting the reprogramming of these cells into cancer-associated fibroblasts (CAFs).

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