9A.08: INTERLEUKINS 33 AND 1B SERUM LEVELS ARE CONNECTED TO COMMON CAROTID ARTERIES REMODELING IN HYPERTENSIVE PATIENTS WITH OBESITY.

OBJECTIVE: To investigate interrelations between interleukin 33 (IL-33) and 1B (IL-1B) serum levels and common carotid arteries (CCA) remodeling in hypertensive patients with obesity.

DESIGN AND METHOD: 80 hypertensive patients (51 obese) have been observed. An ultrasound examination of CCA with estimation of its geometrical type was performed (cut-off value for vascular wall hypertrophy was vascular segment mass >0,275 g/cm, concentric remodeling was diagnosed with relative wall thickness of CCA >0,2). IL-33 and IL-1B serum levels were estimated using ELISA.

RESULTS: IL-33 and IL-1B levels were higher in hypertensive patients (p < 0,001), independently of BMI. Cluster analysis was made to reveal both cytokines' levels impact on CCA geometry. IL-33>73 pg/ml, IL-1B>25 pg/ml was associated with 80,0% prevalence of normal CCA geometry and 20,0% of its concentric hypertrophy. IL-1B>20 pg/ml with IL-33 < 71 pg/ml was characterized by 80,0% prevalence of normal geometry, 10,0% of non-hypertensive concentric remodeling of CCA, 5,0% of concnetric and 5,0% of eccentric hypertrophy. IL-33>71 pg/ml with IL-1B<25 pg/ml was associated with decrease of normal CCA geometry prevalence to 50,0% with increase of concentric hypertrophy rate to 41,7%; other 8,3% patients had eccentric hypertrophy of CCA. IL-33<71 pg/ml, IL-1B<20 pg/ml (p>0,05 vs control group) had 57,9% of normal geometry, 15,8% of concentric remodeling, 15,8% of concnetric hypertrophy and 10,5% of eccentric hypertrophy of CCA.

CONCLUSIONS: IL-33 and IL-1B serum levels were elevated in hypertensive patients independently of presence of obesity. A pronounced isolated increase in IL-33 level was associated with abrupt increase of CCA hypertrophy prevalence, especially its concentric variant. Accompanying increase in IL-1B level reduced this effect.