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Synthesis and antiproliferative activity of some novel benzo-fused imidazo[1,8]naphthyridinones.

Vassiliki Giannouli, Ioannis K Kostakis, Nicole Pouli, Panagiotis Marakos, Pinelopi Samara, Ourania Tsitsilonis
Bioorganic & Medicinal Chemistry Letters 2015 July 2
A number of new substituted fused naphthyridinones has been prepared and their antiproliferative activity was evaluated against a panel of seven human tumor cell lines, including the variant MES-SA/Dx5, reported to be 100-fold resistant to doxorubicin. Certain derivatives exhibited interesting cytotoxic properties, possessing IC50 values in a low μM range.

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