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Haunting the HOXA Locus: Two Faces of lncRNA Regulation.

Nianwei Lin, Jason Dang, Tariq M Rana
Cell Stem Cell 2015 May 8
Long non-coding RNAs (lncRNAs) regulate diverse biological functions through mechanisms ascribed to the lncRNA transcript itself. Now in Cell Stem Cell, Yin et al. (2015) use CRISPR/Cas9-mediated genome editing to demonstrate discrete and opposing roles for the lncRNA Haunt transcript and DNA at the HOXA locus during ESC differentiation.

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