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Research Support, N.I.H., Extramural
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A New B7:CD28 Family Checkpoint Target for Cancer Immunotherapy: HHLA2.

Yanping Xiao, Gordon J Freeman
Clinical Cancer Research 2015 May 16
HHLA2 is a newly identified B7 family member that modulates T-cell functions through interaction with TMIGD2 and possibly a second receptor, with coinhibition in two studies and costimulation in one study. HHLA2 is expressed on a variety of human cancers, and its coinhibitory function makes it a candidate for cancer immunotherapy.

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