[The changes of microbiota and genetic polymorphism of cytokines in patients with irritable bowel syndrome].

The aim of this study was to assess the presence or absence of association between the degree of changes in microbiota and gene polymorphism of cytokines IL-1Ra, IL-1b, TNFa, IL-4, IL-10 in patients with IBS. Materials and methods. The sample consisted of 81 patients, the diagnosis was verified according to the Rome criteria III. Polymorphism genotyping of IL-1Ra, IL-1b, IL-4, TNFα was carried out by PCR. Statistical processing: chi-square test, Fisher's exact test, odds ratio. The relationship between the heterozygous genotype G/A -308 TNFa and clinically relevant microbiological disorders in patients with irritable bowel syndrome was established.