Monoamine oxidase a promoter variable number of tandem repeats (MAOA-uVNTR) in alcoholics according to Lesch typology.

Agnieszka Samochowiec, Magdalena Chęć, Edyta Kopaczewska, Jerzy Samochowiec, Otto Lesch, Elżbieta Grochans, Andrzej Jasiewicz, Przemyslaw Bienkowski, Kołodziej Łukasz, Anna Grzywacz

International Journal of Environmental Research and Public Health 2015 March

BACKGROUND: The aim of this study was to examine the association between the MAOA-uVNTR gene polymorphism in a homogeneous subgroups of patients with alcohol dependence categorized according to Lesch's typology.

METHODS: DNA was provided from alcohol dependent (AD) patients (n=370) and healthy control subjects (n=168) all of Polish descent. The history of alcoholism was obtained using the Polish version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). Samples were genotyped using PCR methods.

RESULTS: We found no association between alcohol dependence and MAOA gene polymorphism.

CONCLUSIONS: Lesch typology is a clinical consequence of the disease and its phenotypic description is too complex for a simple genetic analysis.

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