[130-POS]: Placental abruption and long-term maternal cardiovascular disease mortality: A population-based registry study in Norway and Sweden.

OBJECTIVES: Women with preeclamptic pregnancies have increased risk of long-term cardiovascular mortality. We explored this mortality risk among women with placental abruption, another placental pathology.

METHODS: We used linked Medical Birth Registry and Death Registry data to study cardiovascular disease mortality among women with a first singleton birth between 1967 and 2002 in Norway and 1973 and 2003 in Sweden. Cox regression analysis was used to estimate associations between placental abruption and cardiovascular disease death adjusting for maternal age, education, year of the pregnancy and country.

RESULTS: After an average follow-up of 23 years, 5453 women had died from cardiovascular disease out of a total of 49,944 deaths. Women with placental abruption in first pregnancy (n=4,732) had an increased risk of dying of cardiovascular disease overall (hazard ratio=1.8; 95% confidence interval 1.3, 2.4). The association was stronger for ischemic heart disease (hazard ratio=2.0; 1.4, 2.9) than for stroke (hazard ratio=1.6; 1.0, 2.4). Results persisted after excluding women with other pregnancy complications. Findings did not differ substantially by gestational length of the first pregnancy or attained parity.

CONCLUSIONS: Placental abruption, like other placental complications of pregnancy, may increase women's risk of cardiovascular disease in the decades following reproduction.

DISCLOSURES: L.A. DeRoo: None. R. Skjaerven: None. A.J. Wilcox: None. K. Klungsoyr: None. A. Wikstrom: None. N. Morken: None. S. Cnattingius: None.