We have located links that may give you full text access.
Comparative Study
Journal Article
Review
Human acellular dermal wound matrix for treatment of DFU: literature review and analysis.
Journal of Wound Care 2015 March
UNLABELLED: Diabetic foot ulcers (DFUs) affect a significant number of people and the treatment is challenging and costly. Since only a small portion of patients respond to standard care, the majority require more advanced wound healing interventions. Human acellular dermal matrices-regenerative tissue matrices derived from human tissue and processed from screened donated skin-can aid wound closure by restoring the missing physiological factors to the microenvironment. A literature review of the clinical literature was performed to estimate the comparative effectiveness of one specific human acellular dermal wound matrix (HADWM; Graftjacket regenerative tissue matrix) versus standard care in healing DFUs. Outcomes from three prospective, controlled clinical trials, which included 154 patients with DFUs, were pooled. A comparative analysis revealed a statistically significant reduction in mean wound healing time, 1.7 weeks, as well as a nearly four-fold improvement in the chance of healing ulcers treated with HADWM versus moist wound-care. These pooled results suggest that HADWM may improve healing outcomes for these difficult-to-heal lower extremity wounds.
DECLARATION OF INTEREST: Alexander Reyzelman is a consultant for KCI, an Acelity company.
DECLARATION OF INTEREST: Alexander Reyzelman is a consultant for KCI, an Acelity company.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Essential thrombocythaemia: A contemporary approach with new drugs on the horizon.British Journal of Haematology 2024 April 9
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app