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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Design and synthesis of 1,1-disubstituted-1-silacycloalkane-based compound libraries.
Bioorganic & Medicinal Chemistry 2015 June 2
The introduction of silicon in biologically-relevant molecules represents an interesting medicinal chemistry tactic. Its use is mainly confined to the fine-tuning of specific molecular properties and organosilicon compounds are underrepresented in typical screening libraries. As part of the European Lead Factory efforts to generate novel, drug discovery-relevant chemical matter, the design and synthesis of 1,1-disubstituted-1-silacycloalkane-based compound libraries is described.
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