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MOST: a software environment for constraint-based metabolic modeling and strain design.

Bioinformatics 2015 Februrary 16
SUMMARY: MOST (metabolic optimization and simulation tool) is a software package that implements GDBB (genetic design through branch and bound) in an intuitive user-friendly interface with excel-like editing functionality, as well as implementing FBA (flux balance analysis), and supporting systems biology markup language and comma-separated values files. GDBB is currently the fastest algorithm for finding gene knockouts predicted by FBA to increase production of desired products, but GDBB has only been available on a command line interface, which is difficult to use for those without programming knowledge, until the release of MOST.

AVAILABILITY AND IMPLEMENTATION: MOST is distributed for free on the GNU General Public License. The software and full documentation are available at https://most.ccib.rutgers.edu/.

CONTACT: [email protected].

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