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Journal Article
Desmosomal hotspots, microtubule delivery, and cardiac arrhythmogenesis.
Developmental Cell 2014 October 28
Microtubules can target proteins such as Connexin43 to plasma membrane subdomains. Patel et al. (2014) now show that the structural desmosome complex participates in targeted trafficking of membrane components through interactions between the microtubule network and the N terminus of desmoplakin, a region that is a pathogenic mutation hotspot.
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