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Journal Article
Research Support, Non-U.S. Gov't
Thiophene-3-carboxamide analogue of annonaceous acetogenins as antitumor drug lead.
European Journal of Medicinal Chemistry 2014 October 31
Five novel acetogenin analogues with a furan, thiophene, or thiazole ring were synthesized, and their inhibitory activities toward human cancer cell lines were evaluated. The analogues showed more potent activities than natural acetogenin. One of them, the thiophene-3-carboxamide analogue, strongly inhibited the growth of human lung cancer cell line NCI-H23 in the xenograft mouse assay without critical toxicity.
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